Admission In NIPER Kolkata

Research Area

• Targeting Sphingoshine (SP) receptor for Multiple Sclerosis (MS) and P-glycoprotein to discover new anticancer agents for prostate cancer, Multi drug resistant (MDR) cancer
• Development of new process for API/KSM and Flow Chemistry
• Development of novel inhibitors of Sortase A for attenuating the virulence of Staphylococcus aureus”
• Semi-synthesis of Indolizine, Pyrrolo Quinoline/Isoquinoline based natural product hybrids via 1,3-dipolar cycloaddition
• N2 Fixation by Heterobimetallic Complexes under Visible Light for the Access of Organonitrogen Compounds as Potential Biological Targets
• Live cell fluorescent labelling of Withaferin A targeted protein and their proteomics analysis
• Oligonucletide, RNA, DNA and solid phase synthesis eureka

Research Activities

• Natural products drug discovery (bioactive natural products)
• Extraction, isolation, identification, structural modification (synthesis), bioactivity and mode of action of pharmaceutically important natural products
• Bioassay guided approach
• Metabolomics of medicinal plants
• Development of bioassays for screening plant extracts and isolated compounds
• Genome Analysis (transcriptome, proteome, metabolome)
• Metabolite Profiling
• Herb-Drug Pharmacokinetic interaction
• Standardization of Phytopharmaceuticals using LC-MS, HPLC
• Drug Metabolism of Phytopharmaceuticals

Research Activities

• Development of animal models for human diseases such as Diabetes mellitus, Non alcoholic steatohepatitis, inflammatory bowel disease, neurological disorders
• Scientific evidence for Indian traditional medicine systems such as Ayurveda, Homoeopathy, Siddha, etc.
• Toxicity studies of phtochemicals and synthetic molecules using C. elegans as assay system and rodents
• Exosomes as disease markers and drug delivery agents against various cancer models
• Gene and protein expression studies
• Diabetes and Diabetic complications
• Chemotherapy induced Peripheral Neuropathy
• Trauma induced Peripheral Neuropathy

Research Activities

• Target identification
• Virtual screening of natural compounds and chemical databases against important targets for hit identification
• Ligand-based techniques
• QSAR
• 3D-QSAR
• Ligand based pharmacophore mapping
• Structure-based techniques
• Homology modelling
• Docking
• Target based pharmacophore mapping
• Molecular dynamic simulation
• ADME prediction
• Electronic structure analysis
• Quantum chemical studies of metabolic reaction pathways
• Quantum chemical studies of organic reactions (Computation of transition state, energy of reaction, energy of activation)
• Machine learning and deep learning approaches

• Development of conventional dosage forms including parenteral, biologics for domestic market and later for regulated international markets.
• Cater the analytical needs of small scale pharmaceutical industries through its well-developed analytical service facility.
• Light activated dual drug delivery systems.
• Novel formulations for delivering of drugs to back of the eye .
• Microneedles for delivery of biomolecules .

Research Activities

• Characterization of novel biomaterials from natural biowastes
•  Fabrication of customized implants
•  Hydrogel and medical textiles for wound healing and hemostasis
•  Surface modification, antimicrobial coating of medical devices
•  Bone, skin and cartilage tissue engineering
•  In vitro diagnostics (IVD) based on fluorescent probes and enzyme immobilization
•  Micro/nanodevices for drug delivery, cancer theranostics, live cell imaging
•  3D Bioprinting and Electrospinning
•  Piezoelectric nanomaterials for neo-tissue regeneration
•  Drug-Device combination products

The NIPER Kolkata offers a two-year full-time M.S. (Pharm.) program in Pharmaceutical Analysis since year 2022. The department is equipped with advanced instruments such as GC MS MS, LC MS, HPLC. The department is working on analytical method development for estimation of finished dosage forms, API, profiling of natural products, and marine complex natural products.

Research Area

Ø   Development of LC-MS method and analysis of NDMA impurities

Ø  HPLC method development for Asymmetric compounds/API/finished dosage forms

Ø  Profiling of Marine Natural Products

Ø  Analysis of New Chemical entities (Drug discovery)

Faculty

Dr. Sharada Prasanna Swain, Associate Professor

Dr. Satheesh Kumar Nanjappan, Associate Professor